Live microscopy of multicellular spheroids with the multi-modal near-infrared nanoparticles reveals differences in oxygenation gradients
A. C. Debruyne, I. A. Okkelman, N. Heymans, C. Pinheiro, A. Hendrix, M. Nobis, S. M. Borisov, R. I. Dmitriev
The paper introduces multi-modal near-infrared nanoparticles for live imaging of oxygenation gradients in 3D spheroids, revealing inverted oxygenation patterns and metabolic stratification.
bioRxiv · Dec 11, 2023Cancer Biology