M. Richard

Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction

The paper examines how genetic and species diversity affect ecosystem functions across trophic levels, finding they have opposite impacts.

Transient RNA structures underlie highly pathogenic avian influenza virus genesis

This study identifies transient RNA structures that drive nucleotide insertions leading to the formation of MBCSs in HPAIVs.

Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom-up approach

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.

Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells

The paper identifies virus-like particles in tumor-derived extracellular vesicles and shows they differentially affect dendritic cells compared to other nanoparticles.

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

PACpAInt uses deep learning to identify molecular subtypes of pancreatic adenocarcinoma on histology slides, revealing prognostic heterogeneity and novel subtypes.

Social information use for spatial decision in Zootoca vivipara

This study investigates how Zootoca vivipara use social information from multiple sources to make spatial movement decisions, finding that informant traits and environmental quality influence relocation choices.

DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification

DECONbench benchmarks deconvolution methods for quantifying tumor cell-type heterogeneity by providing datasets, tools, and performance evaluation.

Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model.

This study investigates how CD20-TCB induces T cell-tumor synapses and recruitment in a humanized murine model of DLBCL, revealing a triple mechanism involving synapse formation, resident T cell proliferation, and peripheral T cell recruitment.

Insertions of codons encoding basic amino acids in H7 hemagglutinins of influenza A viruses occur by recombination with RNA at hotspots near snoRNA binding sites

The paper identifies recombination hotspots near snoRNA binding sites in RNA sequences of H7 influenza A viruses that lead to MBCS insertions.

Intraspecific diversity loss in a predator species alters prey community structure and ecosystem functions

This study shows that loss of intraspecific diversity in a predator fish affects prey communities and ecosystem functions through trophic cascades, with both genetic and functional richness playing significant roles.

SARS-CoV-2 is transmitted via contact and via the air between ferrets.

This study shows SARS-CoV-2 spreads via direct contact and air between ferrets, supporting social distancing measures.

Patterns of gene flow across multiple anthropogenic infrastructures: insights from a multi-species approach

The paper examines gene flow impacts of multiple anthropogenic infrastructures on four species, finding that half of genetic variability is explained by LTIs, with roads and railways being the most impactful.

Active cargo positioning in antiparallel transport networks

The paper studies cargo positioning in antiparallel actin networks using colloidal beads and myosin motors, finding that beads accumulate at regions of neutral polarity with motor-dependent precision.