G. Kassiotis

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells

The paper identifies virus-like particles in tumor-derived extracellular vesicles and shows they differentially affect dendritic cells compared to other nanoparticles.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

SARS-CoV-2-host chimeric RNA-sequencing reads do not necessarily signify virus integration into the host DNA

The paper investigates the origin of human-SARS-CoV-2 chimeric RNA-seq reads and finds they likely arise from library preparation rather than viral integration into host DNA.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

Recognition of Z-RNA by ADAR1 limits interferon responses

This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.