Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells
C. Sun, C. Zhou, K. Daneshvar, A. J. Kratkiewicz, A. Ben Saad, A. Hess, J. Y. Chen, J. V. Pondick, S. R. York, W. Li, S. P. Moran, S. Gentile, R. Ur Rahman, Z. Li, R. Sparks, , A. C. Mullen
This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.
bioRxiv · Jul 29, 2023Cell Biology