A. Heuer

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Molecular mechanism of α-latrotoxin action

This paper reveals the molecular mechanism of α-latrotoxin action by determining its high-resolution structures and showing conformational changes during pore formation.

Elucidating the Membrane Binding Process of a Disordered Protein: Dynamic Interplay of Anionic Lipids and the Polybasic Region

This study uses MD simulations and cell culture experiments to show that LKB1's polybasic motif binds anionic lipids dynamically, with key residues and thermodynamic insights provided by a statistical model.

Impact of bilayer composition on the dimerization properties of the Slg1 stress sensor TMD from a multiscale analysis

This study evaluates how bilayer composition affects TMD dimerization using multiscale simulations, finding that ergosterol and phospholipid composition influence TMD-TMD and TMD-lipid interactions.

Effect of Cholesterol vs. Ergosterol on DPPC Bilayer Properties: Insights from Atomistic Simulations

This study compares the effects of cholesterol and ergosterol on DPPC bilayer properties using molecular dynamics simulations, finding cholesterol has a stronger impact due to its planarity and molecular interactions.

Lipid-mediated Association of the Slg1 Transmembrane Domains in Yeast Plasma Membranes

This study investigates how lipid composition influences transmembrane domain (TMD) dimerization in yeast plasma membranes using simulations and live-cell microscopy.

Conformational and interface variability of bivalent RNF4-SIM diSUMO3 interaction

The paper uses molecular dynamics simulations to study the conformational flexibility of the RNF4 diSUMO3 interaction, showing interface variability beyond canonical SIMs.

The novel shapeshifting bacterial phylum Saltatorellota

This paper discovers a new bacterial phylum, Saltatorellota, capable of shape-shifting and amoeba-like movement, challenging the notion of bacterial morphological rigidity.