Elucidating the Membrane Binding Process of a Disordered Protein: Dynamic Interplay of Anionic Lipids and the Polybasic Region
A. Alavizargar, M. Gass, M. P. Krahn, A. Heuer
This study uses MD simulations and cell culture experiments to show that LKB1's polybasic motif binds anionic lipids dynamically, with key residues and thermodynamic insights provided by a statistical model.
bioRxiv · Aug 2, 2023Biophysics