Inflammatory CD4/CD8 double positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology
N. J. Hess, D. P. Turicek, J. Riendeau, S. J. McIlwain, E. Contreras Guzman, K. Nadiminti, A. Hudson, N. S. Callander, M. C. Skala, J. E. Gumperz, P. Hematti, C. M. Capitini
This study identifies CD4+/CD8+ double positive T cells as mediators of xenogeneic GVHD but with limited GVL activity.
bioRxiv · Jan 11, 2022Immunology