Y. Tan

STK19 is a transcription-coupled repair factor that participates in UVSSA ubiquitination and TFIIH loading.

This study identifies STK19 as a critical factor in human transcription-coupled repair, linking CSA, UVSSA ubiquitination, and TFIIH loading.

Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation

This study shows that secretoneurin stimulates ovulation in zebrafish by increasing gene expression in the hypothalamic-pituitary-ovarian axis and inducing ovulation in anovulatory females.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.

INSIHGT: Accessible multimodal systems biology with quantitative molecular phenotyping in 3D

The paper introduces INSIHGT, a 3D spatial biology method for multi-modal molecular phenotyping, and demonstrates its application in mapping cellular structures and identifying novel cell types in human and mouse tissues.

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

Flat-field superresolution structured illumination microscopy with joint temporal-spatial light modulation

This paper introduces a flat-field structured illumination microscopy method to improve field uniformity and enable large-scale imaging of whole cells and pathological samples.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

This study shows thyroid hormone promotes differentiation of medulloblastoma cells, reducing tumor growth by reversing EZH2-mediated repression of NeuroD1.

A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1

This study identifies FoxO1-dependent autophagy as a conserved mechanism for regression of physiological cardiac hypertrophy across species.

Umbrella toxin particles produced by Streptomyces block mycelial growth of competing species

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

Semantical and Geometrical Protein Encoding Toward Enhanced Bioactivity and Thermostability

This paper introduces a pre-training framework that combines sequential and geometric encoders to improve protein variant prediction for enhanced bioactivity and thermostability.

Protein Engineering with Lightweight Graph Denoising Neural Networks

This study introduces a lightweight graph neural network for protein engineering that predicts fitness and guides the design of effective mutants with improved physicochemical properties.

Decoupling of the Onset of Anharmonicity between a Protein and Its Surface Water around 200 K

The paper investigates the onset of anharmonicity in a protein and its surface water around 200 K, finding they are decoupled, with the protein's transition being intrinsic and the water's being a resolution effect.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

The paper shows CAM-A modulators eliminate HBV-infected hepatocytes with high core antigen levels via apoptosis, dependent on de novo core protein translation.

Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

A conditional protein diffusion model generates artificial programmable endonuclease sequences with enhanced activity

This paper introduces CPDiffusion, a conditional protein diffusion model that generates artificial endonuclease sequences with enhanced activity without labeled data.

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Stimulated Raman Photothermal Microscopy towards Ultrasensitive Chemical Imaging

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

Video-rate Mid-infrared Photothermal Imaging by Single Pulse Photothermal Detection per Pixel

This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian aging

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

Vampyroteuthis pseudoinfernalis sp. nov.: the second extant widespread deep sea squid species of Vampyromorpha (Cephalopoda: Coleoidea)

The paper describes a new species of vampire squid, Vampyroteuthis pseudoinfernalis, distinguished by morphological and genetic differences from the known species Vampyroteuthis infernalis.

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis

This study compares single-cell RNA-sequencing data from murine models of eosinophilic esophagitis (EoE) and esophageal squamous cell carcinoma (ESCC) to show that EoE inflammation limits esophageal carcinogenesis through distinct epithelial remodeling.

Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma (DMG)

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions

This study analyzes monkeypox virus-host cell interactions using transcriptome data to identify signaling pathways, biomarkers, and potential drug candidates.

Guild-level microbiome signature associated with COVID-19 severity and prognosis

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.