Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
A. Ignacio, M. Cipelli, T. Takiishi, C. F. Aguiar, F. F. Terra, B. Ghirotto, E. M. Silva, A. Castoldi, Y. T. Magalhaes, T. Antonio, M. I. Hiyane, V. Andrade-Oliveira, F. L. Forti, N. O. S. Camara
This study shows that blocking mTORC2 in CD11c+ myeloid cells reduces colitis by impairing DC migration and Th17 cell infiltration.
bioRxiv · Apr 26, 2023Immunology