A. Dufour

Kinetic properties of optogenetic site-specific DNA recombination by LiCre-loxP

This paper characterizes the kinetic properties of the optogenetic LiCre-loxP system using in vitro and in vivo experiments, revealing temperature-dependent efficiency and a model for recombination synapse formation.

Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM

This study identifies extracellular matrix genes that reduce rapamycin response in LAM cells and suggests repurposed inhibitors as potential therapies.

Cysteine String Protein alpha in Extracellular Vesicle Subtypes: a Proteomic Analysis

The paper identifies CSP/DnaJC5 and its mutants in extracellular vesicle subpopulations through proteomic analysis, suggesting their role in exporting J-domain proteins and client proteins.

FAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen

This study uses FAIMS to identify novel legumain substrates in murine spleen by improving neo-N-termini detection in proteomic analyses.

Integrating melt-electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage

This paper develops a hybrid bioprinting method combining melt-electrowriting and inkjet bioprinting to create structurally organized articular cartilage grafts with improved mechanical properties.

An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy

This study identifies distinct neutrophil states in COVID-19 compared to bacterial ARDS and shows dexamethasone alters these states, reducing mortality risk.

Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonisation

This study identifies eosinophils as critical regulators of intestinal homeostasis, barrier integrity, and motility following microbial colonization.

SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

Metaproteomic Profiling of Fungal Gut Colonization in Gnotobiotic Mice

The paper uses metaproteomic profiling to show that fungal colonization in gnotobiotic mice alters host gut proteome, with implications for immune and metabolic functions.

Lymph flow directs rapid neutrophil positioning in the lymph node in infection

This study shows that lymph flow directs neutrophil migration in lymph nodes during infection by transporting chemokines, and impaired flow leads to persistent infection.

An Atlas of Phosphorylation and Proteolytic Processing Events During Excitotoxic Neuronal Death Reveals New Therapeutic Opportunities

The paper uses proteomic approaches to identify proteins modified during excitotoxic neuronal death and shows that blocking Src kinase protects neurons in a rat model.

Cell Tracking Profiler: a user-driven analysis framework for evaluating 4D live cell imaging data

The paper introduces Cell Tracking Profiler, a framework for analyzing 4D live cell imaging data, and demonstrates its use in studying muscle stem cell behavior during regeneration in zebrafish.

Effects of Substrate Stiffness on Neutrophil Adhesion over L-selectin Coated Endothelial

This study uses Adhesive Dynamics simulations to show that softer substrates enhance neutrophil adhesion through L-selectin interactions.

Identifying Parameters Of Host Cell Vulnerability During Salmonella Infection By Quantitative Image Analysis And Modeling

The paper identifies two sources of host cell vulnerability to Salmonella infection using image analysis and modeling, linking morphological and molecular parameters to infection success.