J. Simpson

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

Viral pIC-pocketing: RSV sequestration of eIF4F Initiation Complexes into bi-phasic biomolecular condensates

This study identifies a mechanism by which RSV sequesters eIF4F initiation complex components into bi-phasic inclusion bodies to facilitate viral mRNA translation.

Structural prediction of chimeric immunogens to elicit targeted antibodies against betacoronaviruses

The paper designs chimeric spike proteins to elicit targeted antibodies against betacoronaviruses using AlphaFold and molecular dynamics, achieving 5/7 accurate predictions.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

Fine-scale variability in coral bleaching and mortality during a marine heatwave

This study tracks coral bleaching and mortality during a marine heatwave, finding that spatial and taxonomic differences in bleaching are driven by environmental factors, habitat complexity, and species composition.

Birnaviridae virus factories show features of liquid-liquid phase separation, and are distinct from paracrystalline arrays of virions observed by electron microscopy

The paper identifies Birnaviridae virus factories as non-membrane-bound structures with liquid-liquid phase separation properties, distinct from paracrystalline virion arrays.

Coronavirus RNA synthesis takes place within membrane-bound sites

This study shows that coronavirus RNA synthesis occurs within membrane-bound compartments in host cells, a finding conserved across all four coronavirus genera, including SARS-CoV-2.

A B73 x Palomero Toluqueo mapping population reveals local adaptation in Mexican highland maize

The paper identifies genomic regions linked to yield and morphological traits in a maize mapping population, revealing local adaptation in highland environments.

Viability markers for determination of desiccation tolerance and critical stages during dehydration in Selaginella species

This paper develops a system to determine desiccation tolerance in Selaginella species using excised tissue and identifies a critical water content threshold for viability loss.

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

The duration of antibiotic treatment is associated with carriage of toxigenic and atoxigenic strains of Clostridioides difficile in dogs.

This study investigates C. difficile carriage in dogs, finding that antibiotic use increases carriage, including toxigenic strains linked to human disease, but not necessarily causing diarrhoea in dogs.

Respiratory syncytial virus sequesters NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling

This paper identifies that RSV sequesters the NF-κB subunit p65 to cytoplasmic inclusion bodies to inhibit innate immune signalling, a mechanism conserved across the Orthopneumovirus genus.

Discrete virus factories form in the cytoplasm of cells co-infected with two strains of the segmented dsRNA virus, infectious bursal disease virus (IBDV), that subsequently coalesce

This study tracks virus factory dynamics during co-infection of two IBDV strains, showing VFs coalesce later in infection, potentially enabling reassortment.

The porcine deltacoronavirus replication organelle comprises double membrane vesicles and zippered endoplasmic reticulum with double membrane spherules

Identification of a novel, NF-κB nucleolar stress response pathway

The paper identifies a novel NF-κB nucleolar stress response pathway triggered by PolI complex disruption, showing TIF-IA degradation and therapeutic relevance in colorectal tumors.

Allele specific expression analysis identifies regulatory variation associated with stress-related genes in the Mexican highland maize landrace Palomero Toluqueno

The paper identifies regulatory variation in stress-related genes in Mexican highland maize using allele-specific expression analysis under benign conditions.