Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding
Q. Chen, P. Cai, T. H. W. Chang, E. Burgener, M. J. Kratochvil, A. Gupta, A. Hargil, P. R. Secor, J. E. Nielsen, A. E. Barron, C. Milla, S. C. Heilshorn, A. J. Spakowitz, P. L. Bollyky
This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.
bioRxiv · Mar 10, 2024 · PreprintMicrobiology