ImmunologybioRxiv
An IRF4-MYC-mTORC1 integrated pathway controls cell growth and the proliferative capacity of activated B cells during B cell differentiation in vivo
D. G. Patterson, A. K. Kania, M. J. Price…·J. M. Boss
This study identifies an IRF4-MYC-mTORC1 pathway critical for B cell proliferation and growth during differentiation, showing IRF4 regulates MYC and mTORC1 to drive metabolic reprogramming and cell cycle progression.
DOI 10.4049/jimmunol.2100440