Hyperinsulinemia promotes HMGB1 release leading to inflammation induced systemic insulin resistance: An interplay between pancreatic beta-cell and peripheral organs
A. Choubey, A. K. Kar, K. Girdhar, T. Chattopadhyay, S. Dogra, S. Kushwaha, B. Medhi, A. Bhansali, C. K. Mantri, U. K. Seetharam, D. Ghosh, P. Mondal
This study shows hyperinsulinemia promotes inflammation via HMGB1 and TLR4 signaling, leading to systemic insulin resistance, and demonstrates naltrexone's protective effects.
bioRxiv · Jul 17, 2019 · PreprintPhysiology