Activating mGlu3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus.
S. Dogra, B. J. Stansley, Z. Xiang, W. Qian, R. G. Gogliotti, F. Nicoletti, C. W. Lindsley, C. M. Niswender, M. E. Joffe, P. J. Conn
This study shows that activating mGlu3 receptors in hippocampal pyramidal cells improves cognitive function in mice by inducing metaplastic changes that enhance synaptic plasticity.
bioRxiv · Oct 27, 2020Pharmacology & Toxicology