BioengineeringbioRxiv
Engineered protein-small molecule conjugates empower selective enzyme inhibition
A. K. Lewis, A. Harthorn, S. M. Johnson…·B. J. Hackel
The paper introduces a platform to create protein-small molecule hybrids (PriSMs) that enhance enzyme inhibition specificity and potency compared to small molecules or proteins alone.
DOI 10.1016/j.chembiol.2021.07.013