Author

A. Karabina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:plant (other)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

L. A. Leinwand· 2 shared A. Bhattacharjee· 1 shared A. Chakraborty· 1 shared A. Meller· 1 shared A. Racca· 1 shared A. Spudich· 1 shared B. Laleu· 1 shared C. A. Johnson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

L. A. Leinwand

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3 papers

Recent·Most cited

Homologous mutations in β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

C. Liu, A. Karabina, A. Meller, A. Bhattacharjee, C. J. Agostino, G. Bowman, K. M. Ruppel, J. A. Spudich, L. A. Leinwand

This study compares the effects of homologous mutations in three muscle myosin isoforms, finding divergent molecular impacts that correlate with disease severity.

bioRxiv · Jul 2, 2023 · PreprintBiophysics

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

D. V. Trivedi, A. Karabina, G. Bergnes, A. Racca, H. Wander, S. Jung, N. Mittal, T. Huijs, S. Ouchida, P. V. Ruijgrok, D. Song, S. Wittlin, P. Mukherjee, A. Chakraborty, E. A. Winzeler, , J. Spudich

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

bioRxiv · Sep 9, 2022 · PreprintPharmacology & Toxicology

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles.

C. A. Johnson, J. Walklate, M. Svicevic, S. M. Mijailovich, C. Vera, A. Karabina, L. A. Leinwand, M. A. Geeves

The paper uses MUSICO to model how cross-bridge cycles of human myosin II isoforms predict muscle fiber contraction characteristics.

bioRxiv · Jun 14, 2019Biochemistry