Author

C. A. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cell Biology· 2 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 6 Approach:statistical model· 5 Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

L. A. LEINWAND· 3 shared M. A. Geeves· 3 shared C. D. Vera· 2 shared J. Walklate· 2 shared M. Svicevic· 2 shared N. A. Riobo-Del Galdo· 2 shared A. Adhikari· 1 shared A. Brodbelt· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

L. A. LEINWAND

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexes

A. J. Timmis, F. Cross, D. S. Gkotsi, H. Ollerton, C. A. Johnson, N. A. Riobo-Del Galdo

This study shows PTCH1 and PTCH2 form active homomeric and heteromeric complexes, with PTCH2 having minimal cholesterol transport but essential cation transport residues, and heteromers can compensate for mutations.

bioRxiv · Aug 8, 2023 · PreprintBiochemistry

Towards Modular Engineering of Cell Signalling: Topographically-Textured Microparticles Induce Osteogenesis via Activation of Canonical Hedgehog Signalling

F. I. Ghuloum, L. A. Stevens, C. A. Johnson, N. A. Riobo-Del Galdo, M. H. Amer

This study shows that topographically-textured microparticles activate Hedgehog signaling and induce osteogenesis in mesenchymal stem cells without exogenous factors.

bioRxiv · Jul 19, 2023Bioengineering

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

G. Tanner, R. Barrow, M. Finetti, S. Ajaib, N. Ahmed, S. Pollock, N. Rippaus, A. F. Bruns, K. Syed, J. Poulter, E. A. Wilson, C. A. Johnson, F. S. Varn, A. Bruning-Richardson, C. Hogg, , L. F. Stead

This study identifies two IDHwt glioblastoma subtypes based on transcriptional response to treatment, with distinct resistance mechanisms and potential therapeutic implications.

bioRxiv · Feb 3, 2023Cancer Biology

Effective conservation decisions require models designed for purpose: a case study for boreal caribou in Ontario's Ring of Fire

M. E. Dyson, S. Endicott, C. Simpkins, J. W. Turner, S. Avery-Gomm, C. A. Johnson, M. Leblond, E. Neilson, R. S. Rempel, P. Wiebe, J. L. Baltzer, J. Hughes, F. E. C. Stewart

The paper evaluates existing models for predicting mining impacts on boreal caribou in Ontario's Ring of Fire and finds they are ill-suited for regional planning due to lack of specificity and variability across caribou ranges.

bioRxiv · Jun 1, 2022Ecology

RNASeq analysis of a Pax3-expressing myoblast clone in-vitro and effect of culture surface stiffness on differentiation.

L. Richardson, D. Wang, R. E. Hughes, C. A. Johnson, M. Peckham

The paper analyzes RNASeq data from a Pax3-expressing myoblast clone to investigate how culture surface stiffness affects differentiation, finding enhanced myogenic gene expression on softer surfaces.

bioRxiv · Sep 5, 2021Cell Biology

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.

A. V. R. Lake, C. E. L. Smith, S. Natarajan, B. Basu, S. K. Best, T. Stevenson, R. Trowbridge, S. N. Grellscheid, J. Bond, R. Foster, C. A. Johnson

The paper identifies ROCK2 as a therapeutic target for ciliopathies through drug and siRNA screens, showing ROCK2 inhibitors could treat cystic kidney disease.

bioRxiv · Nov 26, 2020Cell Biology

Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties

C. D. Vera, C. A. Johnson, J. Walklate, A. Adhikari, M. Svicevic, S. Mijailovich, A. Combs, S. J. Langer, K. M. Ruppel, J. A. Spudich, M. A. Geeves, L. A. LEINWAND

The paper analyzes myosin motor domain mutations in Hypertrophic Cardiomyopathy to compare early and late onset mutations, finding no clear functional differences but identifying distinct changes from DCM mutations.

bioRxiv · Aug 10, 2019Biophysics

Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence.

C. A. Johnson, J. E. McGreig, C. D. Vera, D. P. Mulvihill, M. Ridout, L. A. LEINWAND, M. N. Wass, M. A. Geeves

The paper identifies amino acid sites in β-cardiac myosin associated with body mass and shows that altering these sites can adjust contraction velocity and ADP release rate.

bioRxiv · Jul 2, 2019 · PreprintBiochemistry

The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles.

C. A. Johnson, J. Walklate, M. Svicevic, S. M. Mijailovich, C. Vera, A. Karabina, L. A. Leinwand, M. A. Geeves

The paper uses MUSICO to model how cross-bridge cycles of human myosin II isoforms predict muscle fiber contraction characteristics.

bioRxiv · Jun 14, 2019Biochemistry