A. Khadra

The influence of circadian rhythms on CD8+ T cell proliferation upon vaccination: a mathematical modeling perspective

This paper uses mathematical modeling to show that circadian rhythms influence CD8+ T cell activation during vaccination by affecting molecular targets in the ZAP70 pathway, with implications for vaccine efficacy and timing.

Polarity and mixed-mode oscillations may underlie different patterns of cellular migration

This study uses computational modeling to show that mixed-mode oscillations and adhesion dynamics drive different migration patterns in CHO-K1 cells.

Excitable dynamics in a molecularly-explicit model of cell motility: Mixed-mode oscillations and beyond

This study simplifies a 6D model of cell motility into a 3D ODE model and shows it can exhibit mixed-mode oscillations, which may explain mesenchymal cell motility patterns.

Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity

The paper shows that TdT-mediated TCR diversity, characterized by lower-affinity T cells, aids in controlling chronic infections but not acute ones.

Theoretical Quantification of the Polyvalent Binding of Nanoparticles Coated with Peptide-MHC to TCR-Nanoclusters

The paper develops a multiscale biophysical model to quantify polyvalent binding of pMHC-coated nanoparticles to TCR nanoclusters and examines its role in T cell activation.

High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts

This study investigates how P2Y2 and P2X7 receptors interact to modulate ATP-induced calcium signaling in osteoblasts, revealing biphasic responses and dynamic interplay between receptor subtypes.

Intrinsic Gating Behavior of Voltage-Gated Sodium Channels Predetermines Regulation by Auxiliary β-subunits

This study shows that the intrinsic movement order of voltage-sensing domains in Nav channels determines their susceptibility to regulation by β1 and β3 subunits, explaining variable regulatory effects across channel isoforms.