Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity
Y. Carmi, L. Farhat-Younis, M. Na, A. Zarfin, N. Santana-Magal, A. Richter, A. Khateeb, A. Gutwillig, D. Rasoulouniriana, A. Gleiberman, L. Beck, T. Giger, A. Ashkenazi, A. Barzel, P. Rider
This study modifies myeloid cells to elicit tumor-specific cytotoxicity using chimeric receptors that signal through IgM and bind tumor antigens.
bioRxiv · Sep 30, 2023Immunology