Y. Carmi

Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

This study modifies myeloid cells to elicit tumor-specific cytotoxicity using chimeric receptors that signal through IgM and bind tumor antigens.

TRAF3 Suppression Encourages B Cell Recruitment and Prolongs Survival of Microbiome-Intact Mice with Ovarian Cancer

This study identifies TRAF3 as a tumor-derived immune suppressor in ovarian cancer, showing its role in inhibiting B-cell infiltration and that microbiota presence is required for B-cell activation and tumor progression.

MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.

Antibody repertoire analysis of tumor-infiltrating B cells reveals distinct signatures and distributions across tissues

The paper analyzes the antibody repertoire of tumor-infiltrating B cells in a mouse model of triple-negative breast cancer, finding distinct signatures and migration patterns across tissues.

Transient cell-in-cell formation underlies tumor resistance to immunotherapy

This study identifies transient cell-in-cell formations as a mechanism enabling tumor resistance to immunotherapy, showing they protect tumor cells from immune and chemotherapy attacks.

The Development, Function, and Plasticity of the Immune Macroenvironment in Cancer

The paper defines the systemic immune landscape in response to tumor development across multiple tissues and models, showing dynamic changes and plasticity in the immune macroenvironment.