A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC
Y. Goto, K. Koshizuka, T. Ando, H. Izumi, X. Wu, K. Ford, X. Feng, Z. Wang, N. Arang, M. M. Allevato, A. Kishore, P. Mali, J. S. Gutkind
This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.
bioRxiv · Aug 7, 2023Cancer Biology