T. Ando

Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites

This study uses NMR to show that GRB2's SH3 domains bind PRMs with different affinities and that phosphorylated EGFR binding affects GRB2's structure and domain interactions.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Save GPU RAM Usage in Convolutional Layers to Load Huge Images

This paper introduces a RAM-saving convolutional layer to handle large histopathological images by optimizing GPU memory usage.

A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC

This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.

Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

This study uses high-speed atomic force microscopy to demonstrate the structural dynamics of the E6AP HECT domain and shows how hinge loop flexibility affects Ub chain formation.

Actin binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II

The paper shows that the Rng2CHD domain inhibits actin filament motility on myosin II at low binding ratios, suggesting it modulates actin-myosin interactions through structural changes.

Hidden Markov Modeling of Molecular Orientations and Structures from High-Speed Atomic Force Microscopy Time-Series Images

This paper introduces a hidden Markov model to estimate molecular orientations from HS-AFM time-series data, showing improved robustness compared to frame-by-frame analysis.

Air plasma-activated medium exerts tumor-specific cytotoxicity via the oxidative stress-induced perinuclear mitochondrial clustering

This paper shows that air plasma-activated medium induces tumor-specific cell death through oxidative stress-induced mitochondrial clustering in osteosarcoma and oral cancer cells.

Chained structure of dimeric F1-like ATPase in Mycoplasma mobile gliding machinery

This study determines the structure of a dimeric F1-like ATPase in Mycoplasma mobile gliding machinery, showing it resembles F1-ATPase and supports an evolutionary link.

Unraveling the host-selective toxic interaction of cassiicolin with lipid membranes and its cytotoxicity

This study investigates how cassiicolin toxins interact with plant lipid membranes, showing that their cytotoxicity depends on lipid composition and that specific rubber clones resist the toxins.

Movements of Mycoplasma mobile gliding machinery detected by high-speed atomic force microscopy

This study uses high-speed atomic force microscopy to visualize and analyze the real-time movements of the internal gliding machinery in Mycoplasma mobile.

Biased re-orientation in the chemotaxis of peritrichous bacteria

This study shows that peritrichous bacteria exhibit a biased turn angle during tumbles when swimming up a chemoattractant gradient, enhancing chemotaxis.

Conformational Tuning of Amylin by Charged Styrene-maleic-acid Copolymers

This study shows that charged styrene-maleic-acid copolymers alter amylin aggregation and conformation, with SMAQA inhibiting fibrillation and SMAEA accelerating it.

Inner lumen proteins stabilize doublet microtubules in cilia/flagella

The paper identifies FAP45 and FAP52 as proteins that stabilize microtubules in cilia by binding to their inner structure and preventing detachment.

Repeated inversions at the pannier intron drive diversification of intraspecific colour patterns of ladybird beetles

The paper identifies pannier as a key regulatory gene for color pattern variation in ladybird beetles and shows that inversions and cis-regulatory changes at this gene drive intraspecific diversity.

Dynamic clustering of dynamin-amphiphysin rings regulates membrane constriction and fission coupled with GTP hydrolysis

This study uses EM and HS-AFM to show dynamin-amphiphysin rings cluster during GTP hydrolysis, driving membrane constriction and fission through a novel clusterase mechanism.