K. Hari

Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation

This paper reveals a density-dependent collective metabolic heterogeneity in epithelial cells during contact inhibition of proliferation, showing distinct metabolic patterns in different stages.

Public engagement with biomedical science: An analysis of Black, Hispanic, and General Population adults in the United States

The paper analyzes public engagement with biomedical science among Black, Hispanic, and General Population adults in the U.S., revealing 10 unique mindsets using non-negative matrix factorization.

Cell geometry distinguishes migration-associated heterogeneity in two-dimensional systems

The paper develops an analytical pipeline to identify and characterize functional migratory subsets from 2D time-lapse migration data, revealing previously unappreciated heterogeneity in non-migratory cells.

Spontaneous differentiation leads to emergence of hybrid cell states relate to poor prognosis in oral cancer

This study identifies dynamic phenotypic states in oral cancer cells and their association with poor prognosis through transcriptomic heterogeneity and drug tolerance.

Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotype

The paper investigates immune-evasive strategies of hybrid epithelial/mesenchymal (E/M) cells using a regulatory network model and RNA-seq data, showing they can exhibit high PD-L1 levels without full EMT.

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells

This study develops a mechanistic model showing how non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells arise through EMT dynamics and phenotypic plasticity, suggesting MET inducers as potential therapeutic targets.

Multistability and consequent phenotypic plasticity in AMPK-Akt double negative feedback loop in cancer cells

The paper develops a mathematical model of the AMPK-Akt feedback loop, showing it can generate multistability and phenotypic switching in cancer cells, supported by experimental and clinical data.

AMPK-Fyn signaling promotes Notch1 stability to potentiate hypoxia-induced breast cancer stemness and drug resistance

This study shows AMPK-Fyn signaling stabilizes cleaved Notch1 under hypoxia, enhancing breast cancer stemness and drug resistance.

Suppressing chemoresistance in lung cancer via dynamic phenotypic switching and intermittent therapy

This study shows that intermittent chemotherapy can suppress chemoresistance in lung cancer by preventing the emergence of tolerant cells through dynamic phenotypic switching.