A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings
P. J. del Rivero Morfin, D. Scala Chavez, S. Jayaraman, L. Yang, A. Kochiss, H. M. Colecraft, X. S. Liu, S. O. Marx, A. M. Rajadhyaksha, M. Ben-Johny
This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.
bioRxiv · Sep 22, 2023 · PreprintPhysiology