Author

M. Ben-Johny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Assay:electrophysiology· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

D. C. O. Vieira· 2 shared I. E. Dick· 2 shared P. J. del Rivero Morfin· 2 shared A. Kochiss· 1 shared A. L. Kochiss· 1 shared A. M. Rajadhyaksha· 1 shared B. E. Flucher· 1 shared D. Scala Chavez· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

D. C. O. Vieira

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings

P. J. del Rivero Morfin, D. Scala Chavez, S. Jayaraman, L. Yang, A. Kochiss, H. M. Colecraft, X. S. Liu, S. O. Marx, A. M. Rajadhyaksha, M. Ben-Johny

This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.

bioRxiv · Sep 22, 2023 · PreprintPhysiology

Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of CaV1.3 Channels

P. J. del Rivero Morfin, A. L. Kochiss, K. R. Liedl, B. E. Flucher, M. L. I. Fernandez-Quintero, M. Ben-Johny

The paper investigates how asymmetric conformational changes in CaV1.3 channels mediate voltage- and calcium-dependent inactivation through distinct molecular mechanisms.

bioRxiv · Sep 21, 2023Biophysics

CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms

M. A. Bamgboye, K. G. Herold, D. C. O. Vieira, M. K. Traficante, P. J. Rogers, M. Ben-Johny, I. E. Dick

This study investigates CaV1.2 channelopathies by analyzing mutations in the S6 region, revealing distinct biophysical effects on activation, VDI, and CDI that contribute to diverse clinical outcomes.

bioRxiv · Jun 13, 2022Biophysics

Resolving the molecular fingerprint of the distal carboxy tail in modulating CaV1 calcium dependent inactivation

L. Sang, D. C. O. Vieira, D. T. Yue, M. Ben-Johny, I. E. Dick

The paper identifies critical residues in the IQ and ICDI domains that modulate CaV1 channel inactivation through competitive displacement of CaM.

bioRxiv · Jan 6, 2021 · PreprintBiophysics