4D chromosome reconstruction elucidates the spatial reorganization of the mammalian X-chromosome
A. Lappala, C.-Y. Wang, A. Kriz, H. Michalk, K. Tan, J. Lee, K. Sanbonmatsu
The paper uses 4DHiC to reconstruct 3D chromosome dynamics, showing X-chromosome reorganization during inactivation involves persistent smaller structures and Xist RNA diffusion.
bioRxiv · Jan 21, 2021 · PreprintBiophysics