Author

A. L. Leggett

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Robichaud· 1 shared A. S. Conway· 1 shared B. K. A. Seong· 1 shared B. Nabet· 1 shared D. L. Buckley· 1 shared F. M. Ferguson· 1 shared J. D. Mancias· 1 shared J. E. Bradner· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Robichaud

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1 paper

Recent·Most cited

Cancer BiologybioRxivMar 13, 2020

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

B. Nabet, F. M. Ferguson, B. K. A. Seong…·N. S. Gray

This paper introduces dTAGV-1, a VHL-recruiting dTAG molecule that rapidly degrades FKBP12F36V-tagged proteins, overcoming limitations of CRBN-recruiting dTAGs and enabling combination degrader studies in cells and mice.

DOI 10.1038/s41467-020-18377-w

proteomicsexperimental assay

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