Author

J. E. Bradner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. L. Buckley· 2 shared A. Antolic· 1 shared A. C. Mueller· 1 shared A. Feit· 1 shared A. G. Reidenbach· 1 shared A. L. Leggett· 1 shared A. M. E. Faust· 1 shared A. Rendeiro· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

D. L. Buckley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

Y. LIAO, C.-H. Chen, N. Shah, T. Xiao, A. Feit, M. Yang, C. Cai, S. Gao, P. Xue, Z. Liu, H. Xu, J. Lee, W. Li, S. Mei, R. S. Pierre, , K. Xu

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

bioRxiv · Sep 11, 2020 · PreprintCancer Biology

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

B. Nabet, F. M. Ferguson, B. K. A. Seong, M. Kuljanin, A. L. Leggett, M. L. Mohardt, A. Robichaud, A. S. Conway, D. L. Buckley, J. D. Mancias, J. E. Bradner, K. Stegmaier, N. S. Gray

This paper introduces dTAGV-1, a VHL-recruiting dTAG molecule that rapidly degrades FKBP12F36V-tagged proteins, overcoming limitations of CRBN-recruiting dTAGs and enabling combination degrader studies in cells and mice.

bioRxiv · Mar 13, 2020Cancer Biology

BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy

A. Antolic, H. Wakimoto, Z. Jiao, J. M. Gorham, S. R. DePalma, D. A. Conner, D. Y. Lee, J. Qi, J. G. Seidman, J. E. Bradner, J. D. Brown, S. M. Haldar, C. E. Seidman, M. A. Burke

This study shows BET bromodomain proteins drive inflammatory gene networks in cardiac fibroblasts, contributing to genetic dilated cardiomyopathy, and that JQ1, a BET inhibitor, reduces disease progression.

bioRxiv · Feb 9, 2020Cell Biology

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

S. Sdelci, A. Rendeiro, P. Rathert, G. Hofstaetter, A. Ringler, H. P. Moll, W. You, K. Klavins, B. Guertl, M. Farlik, S. Schick, F. Klepsch, M. Oldach, P. Buphamalai, F. Schischlik, , S. Kubicek

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.

bioRxiv · Oct 10, 2018Cancer Biology