PINK1 supports colorectal cancer growth by regulating the labile iron pool.
B. Chen, N. K. Das, I. Talukdar…·Y. M. Shah
This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.
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6 papers
Recent·Most cited
B. Chen, N. K. Das, I. Talukdar…·Y. M. Shah
This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.
M. Fan, W. Lu, J. Che…·N. Gray
This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.
S. Lin, C. Larrue, B. K. A. Seong…·K. Stegmaier
This study identifies novel therapeutic targets for AML using an in vivo CRISPR screening platform, revealing SLC5A3 as a metabolic vulnerability and MARCH5 as an apoptosis regulator.
N. K. Das, A. Sankar, A. J. Schwartz…·Y. M. Shah
This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.
B. Nabet, F. M. Ferguson, B. K. A. Seong…·N. S. Gray
This paper introduces dTAGV-1, a VHL-recruiting dTAG molecule that rapidly degrades FKBP12F36V-tagged proteins, overcoming limitations of CRBN-recruiting dTAGs and enabling combination degrader studies in cells and mice.
N. Santana-Codina, A. S. Chandhoke, Q. Yu…·J. D. Mancias
This study uses quantitative temporal proteomics to analyze KRASG12C inhibitor responses in cancer models, identifying effective drug combinations to overcome resistance.