Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds
D. A. Hoagland, D. J. B. Clarke, R. Moeller, Y. Han, L. Yang, M. L. Wojciechowicz, A. Lachmann, K. Y. Oguntuyo, C. Stevens, B. Lee, S. Chen, A. Ma'ayan, B. R. tenOever
This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.
bioRxiv · Jul 12, 2020 · PreprintMicrobiology