A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan
T. Y. Li, A. W. Gao, X. Li, Y. J. Liu, R. N. Arey, K. Morales, A. Lalou, Q. Wang, T. Lima, J. Auwerx
This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.
bioRxiv · Jun 13, 2022 · PreprintCell Biology