Author

T. Lima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Organism:C. elegans· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

J. Auwerx· 2 shared X. Li· 2 shared A. Lalou· 1 shared A. Patel· 1 shared A. Rietsch· 1 shared A. W. Gao· 1 shared B. A. Miller· 1 shared B. Avanzino· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersPhysiology

J. Auwerx

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

M. Wohlwend, P.-P. Laurila, L. Goeminne, T. Lima, I. Daskalaki, X. Li, G. von Alvensleben, B. Crisol, R. Mangione, H. Gallart-Ayala, O. Burri, S. Butler, J. Morris, N. Turner, J. Ivanisevic, J. Auwerx

This study shows that reducing CERS1 in skeletal muscle worsens age-related muscle dysfunction in mice and humans, linking it to inflammation and fibrosis.

bioRxiv · Aug 5, 2023 · PreprintPhysiology

A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan

T. Y. Li, A. W. Gao, X. Li, Y. J. Liu, R. N. Arey, K. Morales, A. Lalou, Q. Wang, T. Lima, J. Auwerx

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

bioRxiv · Jun 13, 2022 · PreprintCell Biology

The NLRP3 inflammasome selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates bacterial killing in vivo

M. Minns, T. Lima, K. Liboro, S. Abbondante, B. A. Miller, M. Marshall, J. Tran-Chau, A. Rietsch, G. Dubyak, E. Pearlman

This study shows that Pseudomonas aeruginosa uses ExoS to redirect neutrophil inflammasome signaling from NLRC4 to NLRP3, enhancing bacterial killing and reducing disease severity in mice.

bioRxiv · Apr 7, 2022 · PreprintMicrobiology

Serum proteomics expands on high-affinity antibodies in immunized rabbits than deep B-cell repertoire sequencing alone

S. R. Bonissone, T. Lima, K. Harris, L. Davison, B. Avanzino, N. Trinklein, N. Castellana, A. Patel

This study compares serum proteomics and B-cell repertoire sequencing in rabbits immunized with beta-galactosidase, finding proteomics captures more antibody diversity and partially complements sequencing.

bioRxiv · Jan 31, 2020 · PreprintImmunology