Uncovering and engineering the mechanical properties of the adhesion GPCR ADGRG1 GAIN domain
L. Dumas, M. Marfoglia, B. Yang, M. Hijazi, A. Larabi, K. Lau, F. Pojer, M. Nash, P. BARTH
This study investigates the mechanical properties of the ADGRG1 GAIN domain using single-molecule force spectroscopy and simulations, revealing structural mechanisms that enhance mechanical resistance and informing potential drug design.
bioRxiv · Apr 5, 2023 · PreprintBiophysics