J. Schmidt

European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception

This study investigates how ErCry4a interacts with lipid membranes, showing that its binding depends on lipid physical state and involves specific molecular interactions that may support magnetoreception.

Impaired mitochondrial ketone body oxidation in insulin resistant states

This study shows reduced mitochondrial ketone body oxidation in insulin resistant states across multiple organs in humans and mice.

Developmental origins and evolution of pallial cell types and structures in birds

The paper characterizes the avian pallium's cell types and evolution using single-cell and spatial transcriptomics, revealing conserved and divergent features across amniotes.

Time-Domain Diffuse Optical Tomography for Precision Neuroscience

This paper presents a whole-head time-domain diffuse optical tomography (TD-DOT) system, characterizes its performance, and demonstrates its ability to retrieve cortical activation maps during various tasks.

Machine learning driven image segmentation and shape clustering of algal microscopic images obtained from various water types

This study applies FastSAM for automated algal cell segmentation and clustering in water samples, showing high accuracy for single cells and varying clustering performance.

Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque

This study delivers hIGF1-loaded nanoparticles to the placenta of a pregnant rhesus macaque via uterine artery catheterization, showing successful placental uptake and expression of hIGF1.

Targeting protein-ligand neosurfaces using a generalizable deep learning approach

This paper designs proteins that target neosurfaces from protein-ligand complexes using a deep learning approach, validated experimentally against three drug-bound protein complexes.

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

Tumor-reactive clonotype dynamics underlying clinical response to TIL therapy in melanoma

This study tracks tumor-reactive TIL clonotypes in melanoma patients before and after TIL-ACT to identify factors associated with clinical response.

Dimerisation of European robin cryptochrome 4a

The paper investigates dimerisation of European robin Cry4a through experimental and computational methods, identifying disulphide-linked dimers and proposing their relevance to magnetoreception.

Physical contacts between sparse biofilms promote plasmid transfer and generate functional novelty

This study shows that biofilm collisions promote plasmid transfer between discrete biofilms, with transfer rates influenced by spatial positioning and plasmid dynamics.

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

The paper predicts MHC-II epitope specificities using machine learning, revealing a reverse binding mode in ligands across multiple species.

Reconstructing the ancestral vertebrate brain using a lamprey neural cell type atlas

This study reconstructs the ancestral vertebrate brain by comparing a lamprey neural cell type atlas with data from jawed vertebrates, identifying shared features and evolutionary novelties.

Deep learning can predict multi-omic biomarkers from routine pathology images: A systematic large-scale study

This study shows deep learning can predict multi-omic biomarkers from H&E-stained cancer slides, with 50% of models achieving AUC > 0.633 across 32 cancer types.

Evaluation of a predictive method for the H&E-based molecular profiling of breast cancer with deep learning

The paper validates a deep learning method that predicts breast cancer biomarkers from H&E slides with high accuracy in a clinical setting.

Cellular development and evolution of the mammalian cerebellum

This study uses single-nucleus RNA-sequencing to compare cerebellar development across human, mouse, and opossum, revealing conserved and species-specific gene expression patterns.

The molecular evolution of spermatogenesis across mammals

This study analyzes single-nucleus transcriptomes from testes across eleven mammalian species to uncover molecular evolution patterns in spermatogenesis.

Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts

This study shows ZIKV infection affects trophoblast gene expression and extracellular vesicle content in macaques, suggesting EVs as potential biomarkers for placental infection.

In vitro and in vivo analysis of microvesicle-mediated metastasis using a bright, red-shifted bioluminescent reporter protein of extracellular vesicles

This study uses a bioluminescent reporter to track extracellular vesicles in vivo and shows their role in metastasis by upregulating LC3 in lung tissue.

Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity

This study develops a human hypaxial muscle model from pluripotent stem cells with functional maturation and regenerative capacity for studying muscle biology and disease.

High-throughput single-cell TCR - pMHC dissociation rate measurements performed by an autonomous microfluidic cellular processing unit

The paper develops a microfluidic device to measure TCR-pMHC dissociation rates in single cells and demonstrates its high-throughput capability.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

Relict groups of spiny frogs indicate Late Paleogene-Early Neogene trans-Tibet dispersal of thermophile faunal elements

This study uses genetic data from spiny frogs to infer Late Paleogene-Early Neogene dispersal patterns across the Himalaya-Tibet orogen, supporting trans-Tibet migration of thermophilic species.

Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination

This paper describes the preclinical evaluation of MVA-SARS-2-S, a vector vaccine against SARS-CoV-2, showing it induces immune responses and protects mice from infection.

Correct block-design experiments mitigate temporal correlation bias in EEG classification

This paper refutes claims that block-design EEG experiments are biased by temporal correlation, showing that such correlation has minimal impact on classification accuracy when properly analyzed.

Rewinding the molecular clock in the genus Carabus (Coleoptera: Carabidae) in light of fossil evidence and the Gondwana split: a re-analyses.

This paper reanalyzes the molecular clock dating of the genus Carabus using fossil evidence and the Gondwana split, finding significantly older divergence times than previous studies.

Cover crops improve early season natural enemy recruitment and pest management in cotton production

This study shows that winter cover crops enhance natural enemy populations and reduce pest damage in cotton, leading to cost-competitive yields without increased production costs.

Nociception testing duringfixed-wing ambulance flights.An interventional pilot study on the effects of flight-related environmental changes on the nociception of healthy volunteers.

This study tests nociception in healthy volunteers during air ambulance flights and finds no systematic effects on pain thresholds or detection.

A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) YEATS domain

The paper identifies inhibitory fragments targeting the ENL YEATS domain using crystallography, providing starting points for chemical probe development.

The C-terminal extension landscape of naturally presented HLA-I ligands

The paper identifies frequent C-terminal extensions in HLA-I ligands across multiple alleles and demonstrates their recognition by CD8+ T cells.