RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism
L. Dumas, S. Shin, Q. Rigaud, M. Cargnello, B. Hernandez-Suarez, P. Herviou, N. Saint-Laurent, M. Leduc, M. Le Gall, D. Monchaud, E. Dassi, A. Cammas, S. Millevoi
The paper shows RNA G-quadruplexes regulate mitochondrial function by modulating cytoplasmic mRNA translation of nuclear-encoded mitochondrial proteins, impacting energy metabolism and cancer cell proliferation.
bioRxiv · Jan 29, 2024 · PreprintCancer Biology