An auto-inhibitory mechanism regulates the non-enzymatic functions of a histone demethylase
G. Raiymbek, S. An, N. Khurana, S. Gopinath, S. Biswas, A. Larkin, R. Trievel, U.-s. Cho, K. Ragunathan
The paper shows Epe1 regulates epigenetic inheritance through non-enzymatic interactions with Swi6HP1 and Clr3, independent of its catalytic activity.
bioRxiv · Jun 28, 2019 · PreprintBiochemistry