S. Biswas

Functional redundancy and formin-independent localization of tropomyosin isoforms in Saccharomyces cerevisiae

This study shows that Tpm isoforms in yeast bind actin filaments independently of formin isoforms and exhibit functional redundancy in actin cable maintenance.

PTBP2 promotes cell survival and autophagy in Chronic Myeloid Leukemia by stabilizing BNIP3

This study shows PTBP2 stabilizes BNIP3 to promote cell survival and autophagy in CML, enhancing tumor formation and imatinib resistance.

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

This paper introduces Ingenui-T, a method for rapid CAR T-cell manufacturing from whole blood, showing comparable or better functional activity than conventional methods.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

The paper identifies a mesenchymal-hepatocyte hybrid population that drives liver regeneration by regenerating 50% of new hepatocytes and repopulating liver zones 1 and 3.

Helicity of a tardigrade disordered protein promotes desiccation tolerance

This study shows that helical structure in a tardigrade IDP is necessary for desiccation tolerance, but not sufficient on its own.

Labile assembly of a tardigrade protein induces biostasis

This study identifies a mechanism by which tardigrade CAHS D proteins form gels to protect cells during desiccation, showing that gelation reduces molecular motion and metabolic activity, with reversible effects.

Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV-2 infection and pathogenesis

This study shows that inhibiting host Hsp70 reduces SARS-CoV-2 infection more effectively than Remdesivir by blocking viral entry and autophagy.

Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions

The paper uses live-cell single-molecule tracking to study how H3K9me affects HP1 protein interactions in fission yeast.

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

This study shows that natural and engineered desiccation-tolerant mediators can stabilize Human Blood Clotting Factor VIII without cold-chain storage.

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants

The cost of sympatry: spatio-temporal patterns in leopard dietary and physiological responses to tiger competition in Rajaji Tiger Reserve, India

The paper examines how tiger competition affects leopard diet and physiology in Rajaji Tiger Reserve, finding that sympatry with tigers increases nutritional stress in leopards.

What drives prey selection? Assessment of tiger food habits across the Terai-Arc landscape, India

This study assesses tiger prey selection and livestock predation patterns across the Terai-Arc Landscape in India, identifying key prey species and conflict hotspots.

Bacteriophage anti-defense genes that neutralize TIR and STING immune responses

The paper identifies bacteriophage nucleotidyltransferases and anti-TIR defense genes that inhibit TIR-STING immune responses to promote viral propagation.

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies

This study determines the structure of Pfs48/45, a malaria vaccine candidate, and identifies antibody binding sites that block parasite transmission.

Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection

Therapeutic monoclonal antibodies prevent death from YFV infection.

An intranasal nanoparticle STING agonist has broad protective immunity against respiratory viruses and variants

This study develops NanoSTING, an intranasal nanoparticle STING agonist, showing broad protection against respiratory viruses and variants in animal models.

Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2

This paper describes a method to enhance adenovirus vaccine efficacy by decorating capsid surfaces with antigens, resulting in improved humoral immunity and retained T cell responses.

In-depth immunophenotyping with mass cytometry during TB treatment reveals non-canonical T-cell subsets associated with sputum culture conversion.

The paper uses mass cytometry to analyze T-cell subsets in TB patients, finding specific immune profiles linked to sputum culture conversion during treatment.

Hematopoietic stem and progenitor cells integrate Bacteroides-derived innate immune signals to promote gut tissue repair

This study shows that Bacteroides activates HSPCs in the BM during acute gut inflammation to promote tissue repair, but impairs HSC function in chronic inflammation and aging.

Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms

This study identifies CAHS D as a tardigrade protein that protects against desiccation through multiple mechanisms involving water coordination and slowed molecular motion.

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

Bacillus anthracis chain length, a virulence determinant, is regulated by a transmembrane Ser/Thr protein kinase PrkC

This study identifies PrkC, a transmembrane Ser/Thr kinase in B. anthracis, as a regulator of bacterial chain length, which impacts virulence and pathophysiological outcomes.

Equilibrium morphologies of a macromolecule under soft confinement

The paper studies equilibrium shapes of a semiflexible chain in a soft lipid tubule using simulations and theories, finding a prolate to toroidal coil transition for stiff chains.

Thermodynamics of droplets undergoing liquid-liquid phase separation

The paper studies the thermodynamics of binary mixtures undergoing liquid-liquid phase separation, showing how surface tension and elastic interactions influence droplet formation and stability.

HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization

This study investigates how HP1 proteins recognize H3K9me with high specificity despite low-affinity binding, showing that oligomerization compensates for this and enables heterochromatin localization.

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

This study shows that Grem1 antagonizes BMP signaling to regulate epithelial cell fate during intestinal regeneration.

A novel mode of photoprotection mediated by a cysteine residue in the chlorophyll protein IsiA

This study identifies a cysteine residue in IsiA as critical for photoprotection through excitation energy quenching in cyanobacteria.

Effects of faecal inorganic contents in accurate measures of stress and nutrition hormone in large felines: implications for physiological assessments in free-ranging animals

This study examines how inorganic matter in feces affects stress and nutrition hormone measurements in tigers and lions, proposing corrections to improve accuracy.

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets