Author

U.-S. Cho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:cryo-EM· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2

Frequent Co-Authors

S. An· 4 shared S. H. Park· 3 shared A. Ayoub· 2 shared b. Kim· 2 shared E. Ahn· 2 shared H. Kim· 2 shared S. Park· 2 shared Y. Dou· 2 shared

Activity by Year

2017-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

S. An

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase

E. Ahn, b. Kim, S. Park, A. L. Erwin, S. H. Sung, R. Hovden, S. Mosalaganti, u.-s. Cho

The paper introduces a method to produce graphene-coated grids for cryo-EM and demonstrates their use in determining the structure of sMMOH at high resolution.

bioRxiv · Dec 26, 2021 · PreprintBiochemistry

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

R. Thamkachy, B. Medina-Pritchard, S. H. Park, C. G. Chiodi, J. Zou, M. de la Torre-Barranco, K. Shimanaka, M. A. Abad, C. Gallego Paramo, R. Feederle, E. Ruksenaite, P. Heun, O. R. Davies, J. Rappsilber, D. Schneidman-Duhovny, , A. A. Jeyaprakash

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

bioRxiv · Nov 8, 2021 · PreprintCell Biology

Atmospheric plasma jet device for versatile electron microscope grid treatment

E. Ahn, T. Tang, B. Kim, H. J. Lee, U.-S. Cho

This paper introduces a non-thermal atmospheric plasma jet system for treating electron microscope grids, enabling hydrophilic surface modification without vacuum requirements.

bioRxiv · May 11, 2021 · PreprintBiochemistry

MLL1 Methyltransferase Activity is Regulated by Distinct Nucleosome Binding Modes

A. Ayoub, S. H. Park, Y.-t. Lee, U.-S. Cho, Y. Dou

The paper determines the cryoEM structure of the MLL1 complex bound to a nucleosome and identifies two binding modes, one of which is catalytically inactive.

bioRxiv · Apr 13, 2021Biochemistry

Dismantling and rebuilding the trisulfide cofactor demonstrates its essential role in human sulfide quinone oxidoreductase

A. P. Landry, S. Moon, J. Bonanata, U.-S. Cho, L. Coitino, R. Banerjee

This study demonstrates the essential role of the trisulfide cofactor in human sulfide quinone oxidoreductase by showing its critical impact on catalytic activity and rate enhancement.

bioRxiv · May 19, 2020Biochemistry

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

S. h. Park, A. Ayoub, Y. T. Lee, J. Xu, H. Kim, W. Zhang, B. Zhang, S. An, Y. Zhang, M. A. Cianfrocco, M. Su, Y. Dou, u.-s. cho

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

bioRxiv · Aug 16, 2019Biochemistry

An auto-inhibitory mechanism regulates the non-enzymatic functions of a histone demethylase

G. Raiymbek, S. An, N. Khurana, S. Gopinath, S. Biswas, A. Larkin, R. Trievel, U.-s. Cho, K. Ragunathan

The paper shows Epe1 regulates epigenetic inheritance through non-enzymatic interactions with Swi6HP1 and Clr3, independent of its catalytic activity.

bioRxiv · Jun 28, 2019 · PreprintBiochemistry

MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase

U.-S. Cho, S. J. Lee, H. Kim, S. An, Y. R. Park, H. Jang, S. Park

The paper reports the crystal structure of the MMOH-MMOD complex, revealing how MMOD inhibits MMOH catalytic activity by competing with MMOB and altering the di-iron centre geometry.

bioRxiv · May 26, 2018Biochemistry

Integrative structure investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

J. Yoon, S. J. Kim, S. An, A. Leitner, T. Jung, R. Aebersold, H. Hebert, U.-S. Cho, J.-J. Song

This study investigates the structure of the Importin4_histone H3/H4_Asf1a complex and identifies key interactions between Importin4 and the histone H3 tail.

bioRxiv · Sep 6, 2017Biochemistry