Author

K. Ragunathan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:yeast· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

J. S. Biteen· 3 shared S. Biswas· 3 shared Z. Chen· 3 shared A. Farhat· 2 shared G. Raiymbek· 2 shared A. Diehl· 1 shared A. Larkin· 1 shared A. Levashkevich· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiophysics

J. S. Biteen

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Author profile →

6 papers

Recent·Most cited

Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

B. Moochickal Assainar, K. Ragunathan, R. Baldridge

The paper directly observes Hrd1 autoubiquitination by analyzing its oligomeric states in proteoliposomes and identifies dimers as the minimal functional unit for this process.

bioRxiv · Jun 20, 2023 · PreprintBiophysics

Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions

Z. Chen, M. Seman, A. Farhat, Y. Fyodorova, S. Biswas, A. Levashkevich, L. P. Freddolino, J. S. Biteen, K. Ragunathan

The paper uses live-cell single-molecule tracking to study how H3K9me affects HP1 protein interactions in fission yeast.

bioRxiv · Mar 8, 2023Biophysics

Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice

L. Moritz, S. Schon, M. Rabbani, Y. Sheng, D. Pendlebury, R. Agrawal, C. Sultan, K. Jorgensen, X. Zheng, A. Diehl, K. Ragunathan, Y.-C. Hu, J. Nandakumar, J. Li, K. Orwig, , S. Hammoud

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

bioRxiv · Sep 16, 2021 · PreprintBiochemistry

HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization

S. Biswas, J. Karslake, Z. Chen, A. Farhat, P. Freddolino, J. S. Biteen, K. Ragunathan

This study investigates how HP1 proteins recognize H3K9me with high specificity despite low-affinity binding, showing that oligomerization compensates for this and enables heterochromatin localization.

bioRxiv · Jan 26, 2021Biophysics

The condensation of HP1-????/Swi6 imparts nuclear stiffness

J. F. Williams, I. V. Surovtsev, S. M. Schreiner, Z. Chen, G. Raiymbek, H. Nguyen, Y. Hu, J. S. Biteen, S. Mochrie, K. Ragunathan, M. C. King

This study shows that Swi6 condensation provides mechanical stiffness to the nucleus, demonstrating a mechanical function of biomolecular condensates.

bioRxiv · Jul 2, 2020Cell Biology

An auto-inhibitory mechanism regulates the non-enzymatic functions of a histone demethylase

G. Raiymbek, S. An, N. Khurana, S. Gopinath, S. Biswas, A. Larkin, R. Trievel, U.-s. Cho, K. Ragunathan

The paper shows Epe1 regulates epigenetic inheritance through non-enzymatic interactions with Swi6HP1 and Clr3, independent of its catalytic activity.

bioRxiv · Jun 28, 2019 · PreprintBiochemistry