Nuclear Receptor 5A2 Regulation of Agrp underlies Olanzapine-induced Hyperphagia
R. C. Zapata, D. Zhang, A. Libster, A. Porcu, P. Montilla-Perez, Z. Zhang, S. M. Correa, F. Telese, O. Osborn
This study identifies Nr5a2 as a key driver of olanzapine-induced hyperphagia and weight gain by directly regulating Agrp expression in the hypothalamus.
bioRxiv · Feb 15, 2022Physiology