Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis
N. Dressel, L. Natusch, C. Munz, S. Costas-Ramon, M. N. F. Morcos, A. Loff, B. Hiller, H. Luksch, A. Roesen-Wolff, A. Roers, R. Behrendt, A. Gerbaulet
This study shows that p53 clears genome-damaged hematopoietic cells without needing the cGAS/STING pathway, and that cGAS/STING is not required for coping with DNA damage or preventing leukemia in RER-deficient conditions.
bioRxiv · Jun 24, 2022 · PreprintCell Biology