Cell BiologybioRxivPreprint
Clearance of genome-damaged cells from the hematopoietic system via p53 without contribution by the cGAS/STING axis
N. Dressel, L. Natusch, C. Munz…·A. Gerbaulet
This study shows that p53 clears genome-damaged hematopoietic cells without needing the cGAS/STING pathway, and that cGAS/STING is not required for coping with DNA damage or preventing leukemia in RER-deficient conditions.
DOI 10.1101/2022.06.24.497496