High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling
J. B. MacMillan, R. G. Linington, S. K. Hight, R. S. Lokey, W. Bray, K. Kurita, A. Shaikh, J. Haeckl, S. La, A. Lohith, E. A. McMillan, M. A. White, T. N. Clark, J. Lee, F. Carnevale, , S. Wei
This paper introduces a platform integrating phenotypic screening and metabolomics to improve mechanism of action prediction for natural products, leading to the discovery of novel bioactive compounds.
bioRxiv · Jun 8, 2022Pharmacology & Toxicology