Author

W. Bray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

R. S. Lokey· 2 shared A. Carlin· 1 shared A. Clark· 1 shared A. J. Smith· 1 shared A. Lohith· 1 shared A. Shaikh· 1 shared C. Lagisetti· 1 shared E. A. McMillan· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPharmacology & Toxicology

R. S. Lokey

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation

S. Wang, W. Li, L. Wang, S. K. Tiwari, W. Bray, L. Wu, N. Li, H. Hui, A. Clark, Q. Zhang, L. Zhang, A. Carlin, T. M. Rana

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

bioRxiv · May 1, 2024Microbiology

High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling

J. B. MacMillan, R. G. Linington, S. K. Hight, R. S. Lokey, W. Bray, K. Kurita, A. Shaikh, J. Haeckl, S. La, A. Lohith, E. A. McMillan, M. A. White, T. N. Clark, J. Lee, F. Carnevale, , S. Wei

This paper introduces a platform integrating phenotypic screening and metabolomics to improve mechanism of action prediction for natural products, leading to the discovery of novel bioactive compounds.

bioRxiv · Jun 8, 2022Pharmacology & Toxicology

An Exon Skipping Screen Identifies Antitumor Drugs That Are Potent Modulators of Pre-mRNA Splicing, Suggesting New Therapeutic Applications

Y. Shi, W. Bray, A. J. Smith, W. Zhou, J. Calaoagan, C. Lagisetti, L. Sambucetti, P. Crews, R. S. Lokey, T. R. Webb

The paper identifies antitumor drugs that modulate pre-mRNA splicing through a screening assay, revealing new therapeutic applications and SF3B1 antagonists.

bioRxiv · Mar 21, 2019Cancer Biology