Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis
M. Yokoyama, M. Laabei, E. Stevens, S. Bayliss, N. Ooi, A. O'Neill, E. Murray, P. Williams, A. Lubben, S. Reeksting, G. Meric, B. Pascoe, S. Sheppard, M. Recker, L. Hurst, R. Massey
The paper identifies hidden fitness costs of mupirocin resistance in Staphylococcus aureus using GWAS and proteomics, revealing pleiotropic effects on toxin production and virulence.
bioRxiv · Dec 9, 2017Microbiology