Author

S. Sheppard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Pascoe· 3 shared K. Yahara· 2 shared A. Lubben· 1 shared A. O'Neill· 1 shared B. Martinez-Gonzalez· 1 shared D. Falush· 1 shared D. Sgouras· 1 shared E. Mourkas· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

B. Pascoe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Contrasting genes conferring short and long-term biofilm adaptation in Listeria

W. Monteith, B. Pascoe, E. Mourkas, J. L. Clark, M. Hakim, M. D. Hitchings, N. McCarthy, K. Yahara, H. Asakura, S. Sheppard

This study identifies 273 genes associated with biofilm formation in Listeria monocytogenes through GWAS and 220 genes through RNAseq, finding fewer overlaps than expected, suggesting distinct evolutionary adaptation mechanisms.

bioRxiv · Jun 22, 2023 · PreprintMicrobiology

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

H. A. Thorpe, E. Tourrette, K. Yahara, F. F. Vale, S. Liu, M. Oleastro, T. Alarcon, T. Perets, S. Latifi-Navid, Y. Yamaoka, B. Martinez-Gonzalez, I. Karayiannis, T. Karamitros, D. Sgouras, W. Elamin, , D. Falush

This study shows H. pylori has spread repeatedly from Africa by replacing strains with deleterious mutations through migration and selection.

bioRxiv · Jun 5, 2021Evolutionary Biology

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis

M. Yokoyama, M. Laabei, E. Stevens, S. Bayliss, N. Ooi, A. O'Neill, E. Murray, P. Williams, A. Lubben, S. Reeksting, G. Meric, B. Pascoe, S. Sheppard, M. Recker, L. Hurst, R. Massey

The paper identifies hidden fitness costs of mupirocin resistance in Staphylococcus aureus using GWAS and proteomics, revealing pleiotropic effects on toxin production and virulence.

bioRxiv · Dec 9, 2017Microbiology