P. Williams

Similarities Between Antibiotic-Resistant Escherichia coli from Raw Meat, Commercial Raw Dog Food and Those Causing Extraintestinal Human Infections: A Contemporaneous Geographically Focussed Genomic Epidemiology Study

This study compares antibiotic-resistant E. coli from raw meat, commercial raw dog food, and human infections, finding close genetic links between them.

Polymer-directed inhibition of reversible to irreversible attachment prevents Pseudomonas aeruginosa biofilm formation

This study identifies how specific acrylate polymers inhibit Pseudomonas aeruginosa biofilm formation by preventing the transition from reversible to irreversible attachment.

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through loss of the Rieske cytochrome bc1 sub-unit

This study identifies the Pseudomonas aeruginosa Tat pathway's role in PQS-dependent quorum sensing and biofilm maturation by showing that disruption of the Rieske cytochrome bc1 subunit impairs virulence factor production and eDNA release.

NirA is an alternative nitrite reductase from Pseudomonas aeruginosa with potential as an anti-virulence target

This paper identifies PA4130 as a nitrite reductase in Pseudomonas aeruginosa, named NirA, which shows reduced virulence in multiple models and may serve as an anti-virulence target.

AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii

This paper identifies abaM as a regulator of quorum sensing, biofilm formation, and virulence in Acinetobacter baumannii, showing that its disruption attenuates virulence while increasing AHL production and biofilm formation.

Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response

The paper identifies micro topographies that reduce bacterial attachment and biofilm formation, and show promise in preventing medical device infections in a mouse model.

Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation

This paper develops 3D printing inks that resist bacterial biofilm formation and demonstrate their use in a finger prosthetic to prevent infection.

Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction

The paper expands the topographical design space of biomaterials by replicating natural surfaces and shows new cellular responses not observed with existing synthetic topographies.

Pseudomonas aeruginosa biofilms display carbohydrate ligands for CD206 and CD209 that interfere with their receptor function

This paper identifies CD206 and CD209 as receptors for Pseudomonas aeruginosa biofilm carbohydrates, showing they interfere with receptor function and may modulate immune responses.

Physiotherapist and Podiatrist Independent Prescribing in the United Kingdom: A quasi experimental study

This study compares patient outcomes between physiotherapist and podiatrist independent prescribers and non-prescribers, finding similar quality of life and satisfaction but higher resource use for prescribers.

Cryo-OrbiSIMS for 3D molecular imaging of a bacterial biofilm in its native state

This paper introduces Cryo-OrbiSIMS for 3D molecular imaging of bacterial biofilms, revealing the spatial distribution of quorum sensing molecules and membrane components in Pseudomonas aeruginosa.

Simultaneous tracking of Pseudomonas aeruginosa motility in liquid and at the solid-liquid interface reveals differential roles for the flagellar stators

The paper develops a method to track Pseudomonas aeruginosa motility in liquid and at solid-liquid interfaces, revealing differential roles of flagellar stators motAB and motCD.

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis

The paper identifies hidden fitness costs of mupirocin resistance in Staphylococcus aureus using GWAS and proteomics, revealing pleiotropic effects on toxin production and virulence.

Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production

This study shows that the quorum sensing molecule PQS in Pseudomonas aeruginosa increases siderophore production, which benefits non-producing cheats and affects social competition.