E. Murray

Measles virus co-opts epithelial-to-mesenchymal transition and live cell extrusion to exit human airway epithelia

This paper identifies two host pathways, epithelial-to-mesenchymal transition and live cell extrusion, that facilitate the detachment of MeV-infected cell clusters from human airway epithelia, enhancing viral transmission.

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.

Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression

The paper shows engineered adipocytes can suppress cancer progression by competing for nutrients in multiple cancer types.

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Spatial transcriptomics maps molecular and cellular requirements for CD4+ T cell-dependent immunity to malaria.

This paper uses spatial transcriptomics to map CD4+ T cell and B cell interactions in the spleen during malaria infection, revealing their localization and molecular requirements for immunity.

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function

The paper investigates the opposing roles of ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function in pancreatic cancer stellate cells using 3D chimeric spheroids and bulk-RNA sequencing.

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis

The paper identifies hidden fitness costs of mupirocin resistance in Staphylococcus aureus using GWAS and proteomics, revealing pleiotropic effects on toxin production and virulence.