Author

A. Lyashkov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

C. Ubaida-Mohien· 2 shared L. Ferrucci· 2 shared A. Parveen· 1 shared C. Morrell· 1 shared C. W. Chia· 1 shared D. Riordon· 1 shared E. Lakatta· 1 shared G. Agnetti· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

C. Ubaida-Mohien

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Author profile →

3 papers

Recent·Most cited

Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging

M. G. Perino, M. Calvo-Rubio Barrera, D. Riordon, G. Agnetti, K. Tarasov, A. Parveen, K. Chakir, C. Morrell, I. Ahmet, A. Lyashkov, Y. Lukyanenko, Y. Tarasova, J. Qu, H. Kadioglu, M. Ranek, , E. Lakatta

This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.

bioRxiv · Aug 13, 2023 · PreprintCell Biology

Unbiased Proteomics, Histochemistry, and Mitochondrial DNA Copy Number Reveal Better Mitochondrial Health in Muscle of High Functioning Octogenarians

R. Hepple, C. Ubaida-Mohien, S. Spendiff, A. Lyashkov, R. Moaddel, N. MacMillan, M.-E. Filion, J. Morais, T. Taivassalo, L. Ferrucci

This study compares proteomics, histochemistry, and mitochondrial DNA copy number in muscle samples of high-functioning octogenarians and controls to identify markers of mitochondrial health.

bioRxiv · Nov 2, 2021Physiology

Aging skeletal muscle proteomics finds changes in spliceosome, immune factors, proteostasis and mitochondria

C. Ubaida-Mohien, A. Lyashkov, M. Gonzalez-Freire, R. Tharakan, M. Shardell, R. Ruin Moaddel, R. D. Semba, C. W. Chia, M. Gorospe, R. Sen, L. Ferrucci

This study identifies age-related changes in skeletal muscle proteomics, showing deficits in energy metabolism, increased inflammation, proteostasis, and alternative splicing.

bioRxiv · Jul 11, 2019 · PreprintPhysiology